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Multiple infectious pseudoaneurysms: An autopsy case.

Shuntaro Abe¹, Yoshikatsu Okada², Takako Sato¹

¹Department of Legal Medicine, Division of Preventive and Social Medicine, Faculty of Medicine, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka, Japan.

Legal Medicine (Tokyo, Japan)

|November 24, 2015

Summary

This summary is machine-generated.

A patient with Sjögren syndrome developed multiple arterial pseudoaneurysms, likely due to infection and immunosuppression, leading to a fatal aortic rupture. This case highlights rare complications of long-term steroid therapy and drug abuse.

Keywords:

Infectious arteritis Intravenous drug abuse Multiple pseudoaneurysm Steroid therapy Vasculitic syndrome

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Area of Science:

Cardiovascular Pathology
Infectious Diseases
Rheumatology

Background:

A 47-year-old woman with Sjögren syndrome, hypertension, and a history of thalamic infarction and amphetamine psychosis presented with acute cerebellar infarction.
She had a history of long-term steroid therapy, a known risk factor for immunosuppression.

Observation:

Autopsy revealed multiple pseudoaneurysms in the aorta and coronary arteries.
A ruptured pseudoaneurysm in the aortic root led to hemopericardium and sudden death.

Findings:

Microbial infection of the arterial wall via the vasa vasorum was identified as the likely cause of pseudoaneurysm formation.
Immunosuppression from long-term steroid use and potential intravenous drug abuse may have contributed to the development of these vascular lesions.

Implications:

This case underscores the potential for rare but life-threatening infectious pseudoaneurysms in immunocompromised individuals.
It highlights the importance of considering iatrogenic and substance abuse-related factors in the etiology of complex vascular pathology.