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Generation and Characterization of Right Ventricular Myocardial Infarction Induced by Permanent Ligation of the Right Coronary Artery in Mice
Published on: February 1, 2022
Right ventricular free wall dissection as a rupture tract in left ventricular rupture during acute myocardial
Aya Takada1, Kazuyuki Saito2, Tatsuya Murai3
1Department of Forensic Medicine, Saitama Medical University, Saitama, Japan; Tokyo Medical Examiner's Office, Tokyo, Japan.
Abstract:
Three rare cases of cardiac rupture with right ventricular wall dissection during acute myocardial infarction (AMI) were reported. The cases comprised 2% among our 148 previously reported postinfarction cardiac ruptures with sudden death. The dissections occurred in hearts with biventricular inferior wall AMI and developed between the superficial layers and the deeper layers of inferior wall of the right ventricle. All had an endocardial tear at the basal septum where it meets the inferior free wall of the left ventricle, and had an epicardial tear on the middle inferior wall of the right ventricle. Based on the evidence of the ages of the thrombi of the rupture tracts, delayed epicardial rupture was found besides that soon after the right ventricular dissection.
Insights
Rare cardiac rupture involving right ventricular wall dissection during acute myocardial infarction (AMI) was observed in three cases. This dissection, occurring between myocardial layers, led to both early and delayed ruptures.
Area of Science:
- Cardiology
- Pathology
Background:
- Acute myocardial infarction (AMI) can lead to cardiac rupture, a life-threatening complication.
- Cardiac rupture with right ventricular (RV) wall dissection is an exceptionally rare event.
Observation:
- Three cases of cardiac rupture with RV wall dissection during AMI were identified.
- These cases represented 2% of previously reported postinfarction cardiac ruptures associated with sudden death.
Findings:
- Dissections occurred in hearts with biventricular inferior wall AMI, developing between superficial and deeper layers of the RV inferior wall.
- All cases exhibited an endocardial tear at the basal septum (LV junction) and an epicardial tear on the RV inferior wall.
- Evidence of thrombi ages indicated both early RV dissection and delayed epicardial rupture.
Implications:
- This study highlights a rare but severe mechanism of cardiac rupture following AMI.
- Understanding the layered dissection and timing of rupture is crucial for diagnosing and managing these critical cardiac events.
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