Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.3K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.3K
2.3K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.9K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.9K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.0K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

3.2K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
3.2K
Stem Cell Niche01:26

Stem Cell Niche

6.6K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decitabine reverses innate immune gene suppression in rare melanomas.

Molecular cancer therapeutics·2026
Same author

Targeting liver metastases in uveal melanoma: ATX-LPA mediated immunosuppression and novel therapeutic approaches.

Frontiers in immunology·2026
Same author

TFEB Antagonizes Cardiac Hypertrophy and Failure by Enhancing Lysosomal Capacity and Mitochondrial Function.

Circulation research·2026
Same author

Cervical Skip Metastases and Extensive Central Venous Thrombosis as the Initial Presentation of High-Grade Prostate Adenocarcinoma With Discordant PI-RADS 3 Findings: A Case Report and Diagnostic Challenge.

Clinical case reports·2026
Same author

CLO26-116: Epigenetic Modulation Using Combined oral Decitabine/Cedazuridine (DEC-C) and Nivolumab in Unresectable or Metastatic Mucosal Melanoma: A Phase Ib/II Trial.

Journal of the National Comprehensive Cancer Network : JNCCN·2026
Same author

CLO26-116: Epigenetic Modulation Using Combined oral Decitabine/Cedazuridine (DEC-C) and Nivolumab in Unresectable or Metastatic Mucosal Melanoma: A Phase Ib/II Trial.

Journal of the National Comprehensive Cancer Network : JNCCN·2026

Related Experiment Video

Updated: Mar 29, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

21.9K

Understanding melanoma stem cells.

Nicholas Nguyen1, Kasey L Couts1, Yuchun Luo1

  • 1Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Melanoma Management
|November 24, 2015
PubMed
Summary

Cancer stem cells (CSCs) drive melanoma growth and resistance. Understanding these dynamic cells is key to developing new therapies targeting melanoma progression and metastasis.

Keywords:
cancer stem cellsmelanomamelanoma stem cellstargeting cancer stem cellstumor cell plasticitytumor heterogeneitytumor initiating cells

More Related Videos

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.7K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

9.1K

Related Experiment Videos

Last Updated: Mar 29, 2026

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

21.9K
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

9.7K
Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
11:28

Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics

Published on: May 11, 2016

9.1K

Area of Science:

  • Oncology
  • Cancer Biology
  • Dermatology

Background:

  • Tumors exhibit cellular heterogeneity, with cancer stem cells (CSCs) implicated in tumorigenesis.
  • CSCs play a critical role in melanoma development, progression, drug resistance, and metastasis.
  • Tumor cell populations are dynamic, influenced by the microenvironment and somatic evolution.

Purpose of the Study:

  • To review the current understanding of cancer stem cells (CSCs) in melanoma.
  • To discuss challenges in identifying and characterizing dynamic CSC populations.
  • To explore therapeutic targeting strategies for melanoma stem cells.

Main Methods:

  • Literature review of current research on cancer stem cells.
  • Analysis of the characteristics and functions of melanoma stem cells.
  • Discussion of therapeutic implications and challenges.

Main Results:

  • Cancer stem cells are crucial drivers of melanoma.
  • Melanoma cell populations are dynamic and influenced by external factors.
  • Identifying and characterizing CSCs presents significant challenges.

Conclusions:

  • Targeting cancer stem cells offers potential for novel melanoma therapies.
  • Further research is needed to overcome challenges in CSC identification and therapeutic targeting.
  • Understanding CSC dynamics is essential for effective melanoma treatment and management.