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Updated: Mar 29, 2026
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Published on: August 13, 2019
Dynamic collagen changes in cervix during the first trimester and decreased collagen content in cervical
Asuman Gedikbasi1, Burak Yücel2, Oguz Arslan2
1a Department of Biochemistry , Istanbul Bakirkoy Sadi Konuk Research and Training Hospital , Istanbul , Turkey .
Objective:
To determine the changes in cervical collagen during the first trimester of pregnancy and to evaluate the collagen deficit in cases with a previous diagnosis of cervical insufficiency (CI).
Materials And Methods:
Cervical punch biopsies were obtained from 66 patients divided into three groups: patients with recurrent abortions due to CI (CI group; n = 8); first-trimester abortion group (study group; n = 37), subdivided into three groups according their gestational week (<7, 7-9 and 9-12 weeks), and patients with cervical biopsy due to gynecologic reasons (control group; n = 12). Collagen quantity was determined by a biochemical method that measured the levels of hydroxyproline (HOP) in dry cervix tissue.
Results:
The HOP concentrations were significantly higher at lower gestational ages (p = 0.001). Collagen quantity was lowest in the CI group compared with other groups (p < 0.001).
Conclusion:
This study shows collagen component of cervix decreases as pregnancy advances through the first trimester. Cervical collagen concentration is lower in women with a history of CI compared to controls who has not a history of CI.
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