Related Experiment Videos
Immunopathogenesis of celiac disease
1Department of Medicine, University of California, San Diego, La Jolla 92093.
Immunological Investigations
|January 1, 1989
Summary
Celiac disease susceptibility involves genetic factors, particularly human leukocyte antigen (HLA) genes. A specific HLA haplotype, including HLA-DP, is linked to the condition, potentially influenced by viral proteins.
Area of Science:
- Immunology
- Genetics
- Gastroenterology
Background:
- Celiac disease pathogenesis involves complex interactions between genetic, environmental, and immunological factors.
- Human Leukocyte Antigen (HLA) class II genes are critical for celiac disease susceptibility.
- The HLA-D region, encompassing HLA-DR, DQ, and DP subregions, is implicated.
Purpose of the Study:
- To elucidate the specific genetic components within the HLA-D region associated with celiac disease.
- To investigate the role of extended HLA haplotypes in disease susceptibility.
- To explore potential environmental triggers, such as viral proteins, in celiac disease development.
Main Methods:
- Structural studies of genes within the HLA-D region.
- Analysis of the HLA-DP subregion for disease-associated markers.
- Investigation of potential cross-reactivity between viral and gliadin proteins.
Main Results:
- An extended class II HLA haplotype is associated with celiac disease, including the HLA-DP subregion.
- A polymorphic 4 kilobase Rsa I genomic fragment from a DP beta chain marks this haplotype.
- Evidence suggests viral proteins may contribute to pathogenesis via cross-reactivity with alpha gliadins.
Conclusions:
- The immunopathogenesis of celiac disease is strongly influenced by specific extended HLA haplotypes.
- The HLA-DP subregion plays a role, marked by a specific genomic fragment.
- Viral proteins represent a potential environmental factor in celiac disease, acting through molecular mimicry.