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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Allergic Reactions02:06

Allergic Reactions

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Overview
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Related Experiment Video

Updated: Mar 29, 2026

Murine Model of Allergen Induced Asthma
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Virus/Allergen Interaction in Asthma Exacerbation.

James E Gern1

  • 1Department of Pediatrics and Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

Annals of the American Thoracic Society
|November 24, 2015
PubMed
Summary

Allergies and viral infections worsen asthma exacerbations. Understanding their interactions may improve asthma prevention and treatment strategies.

Area of Science:

  • Immunology
  • Respiratory Medicine
  • Allergy and Clinical Immunology

Background:

  • Asthma exacerbations are frequently linked to viral respiratory infections and allergic rhinitis.
  • The interplay between allergy and viral infections in asthma exacerbations remains incompletely understood.

Purpose of the Study:

  • To review clinical evidence connecting viral infections and allergy to asthma exacerbations.
  • To explore potential interactions between viral infections and allergic responses in the airway.
  • To discuss the implications for preventing and treating asthma exacerbations.

Main Methods:

  • Literature review of clinical studies and research on asthma exacerbations.
  • Analysis of the mechanisms underlying virus-allergen interactions in the respiratory tract.
Keywords:
allergyasthmainterferonrhinovirus

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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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Main Results:

  • Both viral infections and allergies are significant risk factors for asthma exacerbations.
  • Potential interactions include allergy impairing antiviral responses and viruses exacerbating allergic inflammation.

Conclusions:

  • Understanding virus-allergen interactions is crucial for developing targeted strategies.
  • New insights may lead to improved prevention and treatment of asthma exacerbations.