Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

864
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
864
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

699
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
699
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.4K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.4K
Inhaled Medications01:23

Inhaled Medications

992
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
992
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

2.1K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.1K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

1.4K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pressure-enhanced <i>f</i>-electron orbital weighting in UTe<sub>2</sub> mapped by quantum interferometry.

Communications physics·2025
Same author

Healthcare worker perceptions of the FAST TB infection control strategy.

Public health action·2025
Same author

Estimating the Early Transmission Inhibition of New Treatment Regimens for Drug-Resistant Tuberculosis.

The Journal of infectious diseases·2025
Same author

Enhanced triplet superconductivity in next-generation ultraclean UTe<sub>2</sub>.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Quasi-2D Fermi surface in the anomalous superconductor UTe<sub>2</sub>.

Nature communications·2024
Same author

Process measure of FAST tuberculosis infection control demonstrates delay in likely effective treatment.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2019

Related Experiment Video

Updated: Mar 29, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.4K

Inhaled drug treatment for tuberculosis: Past progress and future prospects.

A J Hickey1, P G Durham1, A Dharmadhikari2

  • 1RTI International, Research Triangle Park, 3040 Cornwallis Road, NC 27709, United States.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|November 25, 2015
PubMed
Summary

Rising drug-resistant tuberculosis (TB) necessitates new strategies. Aerosol therapy offers a promising approach to deliver medication directly to the lungs, potentially improving TB control.

Keywords:
AerosolsAntibioticsInhaled therapyMycobacterium tuberculosisPulmonary drug deliveryTuberculosis

More Related Videos

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

8.1K
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K

Related Experiment Videos

Last Updated: Mar 29, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

2.4K
Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
04:22

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

8.1K
System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

9.2K

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Pharmacology

Background:

  • The global incidence of multidrug-resistant tuberculosis (MDR-TB), especially in patients co-infected with human immunodeficiency virus (HIV), has significantly challenged TB control efforts since the 1990s.
  • Formal investigation into aerosol therapy for TB gained traction due to increasing rates of drug-resistant TB.
  • Traditional parenteral drug administration for TB can lead to systemic toxicity.

Purpose of the Study:

  • To explore aerosol therapy as a viable strategy for managing drug-resistant tuberculosis.
  • To highlight the potential benefits of inhaled therapies in overcoming limitations of current TB treatment regimens.
  • To advocate for the consideration of inhaled therapies as a critical component of global TB control.

Main Methods:

  • Review of existing research and case reports on aerosol therapy for tuberculosis.
  • Analysis of the pharmacokinetic advantages of delivering drugs directly to the lungs via aerosolization.
  • Evaluation of aerosol therapy's potential to mitigate systemic toxicity associated with conventional TB treatments.

Main Results:

  • Aerosol therapy enables direct drug delivery to the lungs, achieving target concentrations.
  • The alveolar-capillary interface can be utilized for systemic drug absorption, potentially reducing side effects.
  • The limited pipeline of new anti-TB drugs underscores the need for alternative treatment strategies.

Conclusions:

  • Inhaled therapies represent a critical alternative strategy for achieving global tuberculosis control, particularly against drug-resistant strains.
  • Aerosol delivery offers a targeted approach to lung infections, potentially enhancing treatment efficacy and patient safety.
  • Further research and implementation of aerosol therapy are crucial for combating the growing threat of drug-resistant TB.