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Updated: Mar 29, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
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Men and mice: Relating their ages.

Sulagna Dutta1, Pallav Sengupta2

  • 1Ex-guest Teacher, Department of Physiology, Post-graduation Section, Serampore College, University of Calcutta, Kolkata, West Bengal, India.

Life Sciences
|November 25, 2015
PubMed
Summary
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This study establishes a precise age correlation between mice and humans, finding one human year equals nine mouse days. This improves the accuracy of age-based murine models in biomedical research.

Area of Science:

  • Biomedical Research
  • Comparative Biology
  • Animal Models

Background:

  • Murine models are crucial in biomedical research, comprising 59% of animals used.
  • Mice share significant genetic and physiological similarities with humans, making them valuable research subjects.
  • A key limitation is the vast difference in lifespan between mice and humans.

Purpose of the Study:

  • To establish a precise age correlation between mice and humans.
  • To enhance the accuracy of age-based murine models in biomedical research.
  • To bridge the gap between approximate and accurate age equivalency in translational studies.

Main Methods:

  • This review article synthesizes existing data to establish a precise age relationship.
  • The study focuses on determining age equivalency across different life stages, not just overall lifespan.
Keywords:
AgeDevelopmental biologyHuman ageLaboratory miceMice agePhysiology

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  • Previous work established a rat-to-human age correlation.

    • Main Results:

    • One human year is equivalent to approximately nine mouse days.
    • This correlation is not linear across the entire lifespan when considered holistically.
    • A precise, stage-specific correlation is necessary for accurate age-based modeling.

    Conclusions:

    • Accurate age correlation between mice and humans is essential for improving the translational validity of murine models.
    • This precise relationship allows for more accurate extrapolation of research findings to specific human age groups.
    • This work provides the first detailed, precise mouse-to-human age correlation for research applications.