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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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New insights into microRNAs in skin wound healing

Fatima Fahs1,2,3, Xinling Bi1,2,4, Fu-Shin Yu5,6

  • 1Department of Dermatology, Henry Ford Hospital, Detroit, MI, USA.

IUBMB Life
|November 25, 2015
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of chronic wound healing. This review explores their role in inflammation, proliferation, and remodeling, highlighting therapeutic potential for better wound management.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Regenerative Medicine

Background:

  • Chronic wounds represent a significant healthcare burden, impacting patient morbidity and incurring substantial treatment costs.
  • MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression post-transcriptionally.
  • These miRNAs play crucial roles in the distinct phases of wound healing: inflammation, proliferation, and remodeling.

Purpose of the Study:

  • To review the current understanding of microRNAs involved in the wound healing process.
  • To discuss the therapeutic implications of targeting miRNAs for chronic wound treatment.
  • To identify future research directions in miRNA-based wound healing therapies.

Main Methods:

  • Literature review of studies investigating microRNAs in wound healing.
  • Analysis of in vitro models using primary keratinocytes.
  • Examination of in vivo studies utilizing mouse wound healing models.

Main Results:

  • Specific miRNAs have been identified that influence all three phases of wound healing.
  • Modulation of miRNA expression has been shown to impact the speed and efficacy of wound closure.
  • Evidence supports the involvement of miRNAs in regulating key cellular processes during healing.

Conclusions:

  • MicroRNAs are critical regulators of chronic wound healing.
  • Targeting specific miRNAs offers promising therapeutic strategies for improving wound management.
  • Further research is needed to fully elucidate miRNA functions and translate findings into clinical applications.
Keywords:
drug discoverykeratinocytesmicroRNAspathogenesisskinwound healing

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