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Intracellular antigens as targets for antibody based immunotherapy of malignant diseases

Yangyang Wang1, Xinhui Wang1, Cristina R Ferrone1

  • 1Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.

Molecular Oncology
|November 25, 2015
PubMed

This review discusses the potential use of intracellular tumor antigens as targets of antibody-based immunotherapy for the treatment of solid tumors. In addition, it describes the characteristics of the intracellular tumor antigens targeted with antibodies which have been described in the literature and have been identified in the authors' laboratory. Finally, the mechanism underlying the trafficking of the intracellular tumor antigens to the plasma membrane of tumor cells are reviewed.

Keywords:
Grp78Grp94Hsp70Intracellular tumor antigenMonoclonal antibodiesPRL-3

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