Complement factor H in its alternative identity as adrenomedullin-binding protein 1
Robert B Sim1, Janez Ferluga2, Hanan Al-Rashidi3
1Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK; Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK.
Complement factor H has been extensively studied since its discovery 50 years ago, and its role in the complement system is quite well established. It has another role, however, as a binding protein for the regulatory peptide adrenomedullin. Part of this role appears to be protection of adrenomedullin from proteolytic degradation. The binding interaction is unusual and merits further investigation. Adrenomedullin has potential therapeutic uses in diseases affecting the vasculature, and factor H has been administered with adrenomedullin in some animal models of disease.
Complement factor H has been extensively studied since its discovery 50 years ago, and its role in the complement system is quite well established. It has another role, however, as a binding protein for the regulatory peptide adrenomedullin. Part of this role appears to be protection of adrenomedullin from proteolytic degradation. The binding interaction is unusual and merits further investigation. Adrenomedullin has potential therapeutic uses in diseases affecting the vasculature, and factor H has been administered with adrenomedullin in some animal models of disease.
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