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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
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Cervical cancer stem cells.

Tingting Yao1,2, Rongbiao Lu3, Yizhen Zhang4

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Cancer stem cells (CSCs) drive cancer, but cervical CSCs remain elusive. Research into their origin, markers, pathways, and niche may unlock new cervical cancer treatments.

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Area of Science:

  • Oncology
  • Cell Biology

Background:

  • Cancer stem cells (CSCs) are recognized drivers of tumor initiation and progression.
  • Their role in various cancers is increasingly understood, prompting investigation into specific cancer types.

Purpose of the Study:

  • To review the current understanding of cervical cancer stem cells (CSCs).
  • To explore the origin, identification markers, signaling pathway alterations, and niche of cervical CSCs.

Main Methods:

  • Literature review focusing on cervical CSCs.
  • Analysis of purported CSC origin, identification markers, signaling pathways, and the CSC niche in cervical cancer.

Main Results:

  • Cervical CSCs are not yet definitively identified or characterized.
  • Key areas of investigation include their origins, specific markers, associated signaling pathways, and the microenvironment (niche).

Conclusions:

  • Despite challenges in definitive identification, cervical CSCs represent a promising area for therapeutic targeting.
  • Further research into cervical CSCs could lead to novel treatment strategies for cervical cancer.