Related Experiment Video

Updated: Mar 29, 2026

Isolation of Mouse Lung Dendritic Cells

Isolation of Mouse Lung Dendritic Cells

Published on: November 22, 2011

Role of dendritic cell-pathogen interactions in the immune response to pulmonary cryptococcal infection

Alison J Eastman^1,2, John J Osterholzer^1,2,3, Michal A Olszewski^1,2,3

¹Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

Future Microbiology

|November 25, 2015

Abstract:

This review discusses the unique contributions of dendritic cells (DCs) to T-cell priming and the generation of effective host defenses against Cryptococcus neoformans (C.neo) infection. We highlight DC subsets involved in the early and later stages of anticryptococcal immune responses, interactions between C.neo pathogen-associated molecular patterns and pattern recognition receptors expressed by DC, and the influence of DC on adaptive immunity. We emphasize recent studies in mouse models of cryptococcosis that illustrate the importance of DC-derived cytokines and costimulatory molecules and the potential role of DC epigenetic modifications that support maintenance of these signals throughout the immune response to C.neo. Lastly, we stipulate where these advances can be developed into new, immune-based therapeutics for treatment of this global pathogen.

Keywords:

Cryptococcus neoformans TLR9 TNF-α cryptococcal virulence factors dendritic cells epigenetics mouse model

More Related Videos

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Analysis of Pulmonary Dendritic Cell Maturation and Migration during Allergic Airway Inflammation

Published on: July 23, 2012

Related Concept Videos

Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

Defense Against Bacterial Pathogens

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...

Cystic Fibrosis: Pathogenesis

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

Pneumonia II: Pathophysiology

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

Articles linked to this work by shared authors, journal, and citation graph.

Deployment-related respiratory health: bridging the gap between clinical and epidemiological associations and disease mechanisms: an official American Thoracic Society Workshop Report.

Annals of the American Thoracic Society·2026

Genetically predicted cytotrophoblast gene expression is associated with birth weight and adult body mass index.

Placenta·2026

Development of peribronchiolar fibrosis is associated with local immune and MAPK pathway activation in a murine model of deployment-related constrictive bronchiolitis.

Frontiers in public health·2026

Comparative analysis of V ˙ O 2 prediction equations using a novel web-based application: an illustrative example in formerly deployed military veterans.

Frontiers in physiology·2026

Comparison of cytokine responses to group B Streptococcus infection in a human maternal-fetal interface organ-on-a-chip system and ex vivo culture model of human gestational membranes.

Infection and immunity·2025

Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface.

Frontiers in lab on a chip technologies·2025

See all related articles