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Related Concept Videos

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Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Blood Transfusion and Agglutination02:45

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
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Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
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Related Experiment Video

Updated: Mar 29, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
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Cord blood banking and quality issues.

Amanda Murphy1, David McKenna1, Jeffrey McCullough1

  • 1Department of Pathology and Laboratory Medicine, University of Minnesota, Minneapolis, Minnesota.

Transfusion
|November 25, 2015
PubMed
Summary

Cord blood quality guidelines were evaluated for effectiveness. While many units had issues, these did not impact transplant success, suggesting a review of current cord blood banking regulations may be beneficial.

Area of Science:

  • Hematology
  • Cellular Therapy
  • Regulatory Science

Background:

  • Food and Drug Administration (FDA) guidelines aim to ensure the quality and safety of cord blood for transplantation.
  • Evaluating the effectiveness of these FDA guidelines is crucial for optimizing cord blood banking practices.

Purpose of the Study:

  • To assess the clinical impact of quality issues identified in cord blood units processed for transplantation.
  • To determine if current FDA guidelines for cord blood quality assurance are effective in practice.

Main Methods:

  • A cell therapy quality system was applied to cord blood units at the University of Minnesota (2011-2013).
  • Quality issues were categorized by their potential clinical impact: likely, potentially, or unlikely.
  • Data from 249 umbilical cord blood (UCB) units from 16 cord blood banks were analyzed.

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Main Results:

  • 159 out of 249 UCB units (64%) had 245 identified issues, primarily related to medical history (48%) and quality control (49%).
  • Units with quality issues were not more likely to fail engraftment.
  • No specific type of quality issue was linked to transplant failure.
  • A decrease in issues per unit was observed compared to a study from 10 years prior.

Conclusions:

  • Despite high costs associated with cord blood collection, testing, processing, and storage, some activities may not enhance product quality or safety.
  • A review of current FDA guidelines is recommended to assess their value based on accumulated experience and data.
  • Optimizing regulatory processes could improve efficiency without compromising cord blood transplant outcomes.