Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vascular Spasm01:16

Vascular Spasm

4.8K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
4.8K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

775
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
775
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

849
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
849
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.6K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.6K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

18.6K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
18.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Genetics of cryopyrin-associated periodic syndrome].

Zeitschrift fur Rheumatologie·2017
Same author

[Autoinflammatory syndromes : Practical approach to diagnostics and therapy].

Zeitschrift fur Rheumatologie·2016
Same author

[Cryopyrin-associated periodic syndrome].

Zeitschrift fur Rheumatologie·2012
Same author

[Autoinflammatory syndromes/fever syndromes].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete·2011
Same author

[Periodic fever syndrome/autoinflammatory syndrome].

Zeitschrift fur Rheumatologie·2009
Same author

Pediatric rheumatology: autoimmune mechanisms and therapeutic strategies.

Immunology today·1998

Related Experiment Video

Updated: Mar 29, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

7.7K

[Childhood vasculitis].

J B Kümmerle-Deschner1, J Thomas2, S M Benseler3

  • 1Klinik für Kinder- und Jugendmedizin, Autoinflammation Reference Center Tübingen, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 1, 72076, Tübingen, Deutschland. kuemmerle.deschner@uni-tuebingen.de.

Zeitschrift Fur Rheumatologie
|November 25, 2015
PubMed
Summary

Childhood vasculitis, though often of unknown cause, has updated classifications and available treatments. Early diagnosis and intervention are key to preventing long-term damage from these rare inflammatory conditions.

Keywords:
Granulomatosis with PolyangiitisKawasaki syndromePolyarteritis nodosaPurpura Schoenlein-HenochTakayasu Arteritis

More Related Videos

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
08:27

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

Published on: January 27, 2015

14.8K
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.7K

Related Experiment Videos

Last Updated: Mar 29, 2026

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases
07:47

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Published on: December 6, 2016

7.7K
Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
08:27

Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.

Published on: January 27, 2015

14.8K
Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
05:14

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

1.7K

Area of Science:

  • Pediatric rheumatology
  • Immunology
  • Vascular medicine

Context:

  • Primary vasculitides are rare in children, with Schönlein-Henoch purpura and Kawasaki's syndrome being most common.
  • Etiology is often unknown, but infections may trigger autoinflammatory responses in susceptible individuals.

Purpose:

  • To review the classification, pathogenesis, clinical manifestations, and therapy of childhood vasculitis.
  • To provide an overview of current diagnostic and therapeutic approaches for pediatric vasculitis.

Summary:

  • Childhood vasculitis classification has been updated since 2008, adapting adult criteria.
  • Therapeutic recommendations are largely based on adult studies.
  • Current review covers updated classifications, pathogenesis, clinical features, and treatment guidelines for pediatric vasculitis.

Impact:

  • Improved understanding of childhood vasculitis aids early diagnosis and timely treatment.
  • Effective management strategies can prevent irreversible impairment in affected children.
  • Advances in diagnostics and therapeutics offer better outcomes for pediatric vasculitis patients.