[The HLA system in the Moroccan population: General review]

Area of Science:

• Immunogenetics
• Population Genetics
• Anthropology

Background:

• The Moroccan population presents significant ethnic and genetic diversity, making it a valuable model for studying Human Leukocyte Antigen (HLA) polymorphism.
• Existing research on HLA diversity within the Moroccan population is limited, highlighting a gap in knowledge regarding histocompatibility.

Purpose of the Study:

• To consolidate current knowledge on HLA diversity, anthropology, transplantation, and disease associations in the Moroccan population.
• To establish a foundational database of healthy Moroccan HLA polymorphism.
• To explore potential applications in identifying immigration patterns and understanding disease associations.

Main Methods:

• Comprehensive literature review focusing on HLA polymorphism in Morocco.
• Analysis of existing data to establish a baseline of Moroccan HLA diversity.
• Identification of potential associations between HLA alleles and prevalent diseases.

Main Results:

• The Human Leukocyte Antigen (HLA) system is not fully characterized in the Moroccan population.
• Initiation of a database for healthy Moroccan HLA polymorphism.
• Potential to identify immigration flows and relationships with global populations.
• Potential to reveal associations between specific HLA alleles and common pathologies.

Conclusions:

• Further exploration of HLA polymorphism in Morocco is warranted.
• The developed database can serve as a resource for population genetics and anthropological studies.
• Understanding Moroccan HLA diversity can contribute to advancements in transplantation and personalized medicine.
• Addressing barriers to HLA research in Morocco is crucial for future progress.