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Updated: Jul 1, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
[Possible neuropharmacological regulation of chemical carcinogenesis caused by diethylnitrosamine]
Abstract:
The effect of a number of neurotropic drugs on diethylnitrosoamine (DENA)-induced chemical carcinogenesis was studied by applying pharmacological, morphological and biochemical techniques. Atropine stimulated significantly the rat liver and esophagus carcinogenesis, whereas the alpha-adrenoblocking agent, a pyrrhoxane analogue, and, particularly, proserine inhibited these processes. All animals treated with DENA demonstrated a significant increase of liver mitochondrial monoaminoxidase activity. These findings as well as the evidence of a stimulating effect of exogenous norepinephrine on carcionogenesis, together with the literature sources on carcinogenic and modifying carcinogenesis action of neurotropics allow the authors to formulate a concet of the trigger role played by catecholamines in the DENA-induced cell transformation and carcinogenesis.
Insights
Neurotropic drugs impact chemical carcinogenesis. Atropine stimulated cancer, while alpha-adrenoblocking agents inhibited it, suggesting catecholamines trigger diethylnitrosamine-induced cell changes.
Area of Science:
- Pharmacology
- Toxicology
- Biochemistry
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