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Mitosis and Cytokinesis

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

Mitosis and Cytokinesis

Mitosis and Cytokinesis

In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
The processes of the cell cycle occur over approximately 24 hours (in typical human cells) and in two major distinguishable stages. The...

Mitosis and Cytokinesis

Mitosis and Cytokinesis

Mitosis And Cytokinesis

Mitosis And Cytokinesis

Meiosis I

Meiosis I

Meiosis is a carefully orchestrated set of cell divisions, the goal of which—in humans—is to produce haploid sperm or eggs, each containing half the number of chromosomes present in somatic cells elsewhere in the body. Meiosis I is the first such division, and involves several key steps, among them: condensation of replicated chromosomes in diploid cells; the pairing of homologous chromosomes and their exchange of information; and finally, the separation of homologous chromosomes by...

Meiosis I

Meiosis I

Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...

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Related Experiment Video

Updated: Mar 29, 2026

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

Published on: June 24, 2019

Mitosis is swell.

Evgeny Zatulovskiy¹, Jan M Skotheim²

¹Department of Biology, Stanford University, Stanford, CA 94305.

The Journal of Cell Biology

|November 25, 2015

Summary

This summary is machine-generated.

Cell volume typically correlates with dry mass. However, new research shows cells rapidly swell upon entering mitosis, then return to normal size before dividing.

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Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy

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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

Area of Science:

Cell Biology
Molecular Biology

Background:

Cell volume and dry mass are generally considered to be correlated.
Understanding cell volume dynamics is crucial for comprehending cell cycle progression.

Purpose of the Study:

To investigate cell volume changes during the cell cycle, specifically during entry into mitosis.
To utilize novel live-cell imaging techniques to observe these dynamic processes.

Main Methods:

Live-cell imaging techniques were employed to monitor cell volume in real-time.
Quantitative analysis of cell dimensions and mass was performed during mitosis.

Main Results:

Entry into mitosis was observed to coincide with rapid cell swelling.
This swelling was reversed before the completion of cell division, returning cells to their original volume.
The findings challenge the direct correlation between dry mass and volume during specific cell cycle phases.

Conclusions:

Cell volume is not strictly correlated with dry mass throughout the entire cell cycle.
Significant, transient cell swelling occurs during the G2/M transition.
Dynamic volume regulation plays a role in mitotic progression and cell division.