Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Modulating IL-11-dependent matrix stiffness to delay ovarian aging.

Nature aging·2026

Same author

CAV1-dependent mitochondrial transfer from hucMSCs reprograms epithelial lipid metabolism to relieve pulmonary fibrosis.

Stem cell research & therapy·2026

Same author

Baozhu Granule as a Novel Treatment Strategy for Diminished Ovarian Reserve: A Prospective Clinical Trial.

Rejuvenation research·2026

Same author

Prokaryotically expressed IBDV VP2 virus-like particles: Stability and protective efficacy.

Microbial pathogenesis·2026

Same author

A ferritin-based mosaic-like nanovaccine elicits effective cross-protection against H1N1 and H3N2 swine influenza viruses.

Journal of nanobiotechnology·2026

Same author

Enhanced Radio-sensitization of Glioblastoma using a Dendrimer-Based Metformin Nano-formulation through Direct Tumor Suppression and Indirect Immune Modulation.

bioRxiv : the preprint server for biology·2026

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Polymer-based vehicles for therapeutic peptide delivery.

Jinjin Zhang¹, Swapnil S Desale¹, Tatiana K Bronich¹

¹Department of Pharmaceutical Sciences & Center for Drug Delivery & Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Therapeutic Delivery

|November 25, 2015

Summary

Polymeric materials offer promising solutions for peptide drug delivery, overcoming challenges like degradation and short circulation. This review explores various polymer-based systems for enhanced peptide therapeutics.

More Related Videos

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

Related Experiment Videos

Last Updated: Mar 29, 2026

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid

Published on: February 27, 2019

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

Area of Science:

Biomaterials Science
Pharmaceutical Sciences
Drug Delivery

Background:

Peptides are increasingly recognized as valuable therapeutics.
Clinical use of peptide drugs is limited by degradation, short half-life, poor barrier crossing, and immunogenicity.
Polymeric materials present versatile solutions for peptide delivery systems.

Purpose of the Study:

To review current and potential polymer-based systems for peptide drug delivery.
To discuss strategies for overcoming challenges in peptide therapeutics.

Main Methods:

Literature review of polymer-based peptide delivery systems.
Analysis of formulation strategies and their impact on peptide stability and release.

Main Results:

Various polymer-based vehicles have been developed to stabilize peptides and control release rates.
No single polymer or formulation strategy is universally ideal for all peptide drugs.

Conclusions:

Polymer-based systems are crucial for advancing peptide therapeutics.
Further research is needed to identify optimal polymer strategies for diverse peptide drugs.