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The Association between Bone Age Advancement and Insulin Resistance in Prepubertal Obese Children

H S Lee1, Y S Shim2, H R Jeong1

  • 1Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital, Suwon, Korea.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|November 25, 2015
PubMed

Insights

Obese children with higher insulin levels and insulin resistance show advanced bone age (BA). This suggests insulin may play a role in skeletal maturation, impacting growth in children.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Skeletal Development

Background:

  • Obesity is linked to advanced bone age (BA), but the mechanisms are not fully understood.
  • Understanding factors influencing skeletal maturation in obese children is crucial for growth assessment.

Purpose of the Study:

  • To investigate the association between bone age maturation and insulin levels in obese children.
  • To explore the role of insulin resistance in skeletal development among prepubertal obese youth.

Main Methods:

  • A cross-sectional study involving 93 prepubertal obese children.
  • Measurement of anthropometric data and hormonal values, including fasting insulin and HOMA-IR.
  • Classification of subjects into groups based on the difference between bone age and chronological age (BA-CA).

Main Results:

  • Children with advanced bone age (BA-CA > 1 year) exhibited significantly higher HOMA-IR and fasting insulin levels.
  • Bone age advancement (BA-CA) showed significant correlations with fasting insulin, HOMA-IR, and QUICKI.
  • Homeostatic model assessment for insulin resistance (HOMA-IR) emerged as an independent predictor of bone age advancement.

Conclusions:

  • Obese children with hyperinsulinemia and insulin resistance demonstrate advanced bone age.
  • These findings indicate a potential role for insulin in influencing skeletal maturation.
  • Further research is warranted to elucidate the precise mechanisms linking insulin and bone development in pediatric obesity.
Abstract

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