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Sleep Disturbances in Schizophrenia.

Jayesh Kamath1, Sundeep Virdi1, Andrew Winokur1

  • 1Department of Psychiatry, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-6415, USA.

The Psychiatric Clinics of North America
|November 25, 2015
PubMed
Summary
This summary is machine-generated.

Sleep disturbances are common in schizophrenia, impacting illness severity. Abnormal sleep patterns in schizophrenia correlate with clinical issues and may involve neurotransmitter and clock gene dysregulation.

Keywords:
Antipsychotic medicationClinical correlatesClock genesNeurotransmitterPolysomnographySchizophreniaSleep disturbances

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Area of Science:

  • Psychiatry
  • Sleep Medicine
  • Neuroscience

Background:

  • Sleep disturbances are highly prevalent in schizophrenia patients.
  • These sleep issues significantly contribute to the illness's morbidity and mortality.
  • Consistent findings emerge from both subjective and objective sleep assessments in this population.

Purpose of the Study:

  • To review consistent findings in sleep disturbances among schizophrenia patients.
  • To explore the correlation between sleep structure abnormalities and clinical aspects of schizophrenia.
  • To discuss the potential role of neurotransmitter systems and clock genes in the pathophysiology of these sleep disturbances.

Main Methods:

  • Review of subjective and objective sleep assessments in schizophrenia.
  • Analysis of correlations between sleep structure abnormalities and clinical features.
  • Examination of potential pathophysiological mechanisms, including neurotransmitter and clock gene involvement.

Main Results:

  • Consistent abnormalities in sleep structure are identified in schizophrenia patients.
  • These sleep abnormalities correlate with significant clinical aspects of the illness.
  • Neurotransmitter system disruption and clock gene dysregulation are implicated in schizophrenia-related sleep disturbances.

Conclusions:

  • Sleep disturbances are a critical component of schizophrenia, linked to clinical outcomes.
  • Understanding sleep structure abnormalities is key to managing schizophrenia.
  • Antipsychotic medications impact sleep structure and are vital for treating sleep disturbances in schizophrenia.