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Related Concept Videos

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T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Related Experiment Video

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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Th17 regulating lower airway disease.

Lorenzo Cosmi1, Francesco Liotta, Francesco Annunziato

  • 1aDepartment of Experimental and Clinical Medicine, University of Florence bImmunology and Cell Therapy Unit cRegenerative Therapy Unit, AOU Careggi Hospital, Florence, Italy.

Current Opinion in Allergy and Clinical Immunology
|November 25, 2015
PubMed
Summary
This summary is machine-generated.

T helper 17 (Th17) cells are implicated in severe asthma. Accumulation of Th17 cells in asthma correlates with airway obstruction and steroid resistance, suggesting targeted therapies may benefit these patients.

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Area of Science:

  • Immunology
  • Respiratory Medicine

Background:

  • T helper 17 (Th17) lymphocytes play a crucial role in chronic immune diseases like asthma and COPD.
  • Understanding Th17 cell involvement is key to addressing severe respiratory conditions.

Purpose of the Study:

  • To review the current knowledge on Th17 cells in the pathogenesis of asthma phenotypes.
  • To discuss the role of Th17 cells in chronic obstructive pulmonary disease (COPD).

Main Methods:

  • Literature review of studies on Th17 cells in asthma and COPD.
  • Analysis of recent findings regarding Th17 cell populations in bronchoalveolar lavage fluid.

Main Results:

  • Th17 cells and Th17/Th2 cells are found in asthmatic patients' airways.
  • These cell populations correlate with airway obstruction and steroid resistance.
  • Patients often exhibit severe, steroid-resistant asthma with neutrophilic inflammation.

Conclusions:

  • Targeted therapies against IL-17 may benefit severe asthma with neutrophilic inflammation.
  • Personalized treatment requires defining clinical phenotypes and inflammatory endotypes.
  • Further research into Th17-mediated pathways is warranted for effective asthma management.