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Dysphonia after Bevacizumab Rechallenge: A Case Report
Corey A Carter1, Scott Z Caroen2, Arnold L Oronsky3
1Walter Reed National Military Medical Center, Bethesda, Md., USA.
Case Reports in Oncology
|November 25, 2015
Summary
Severe voice changes (dysphonia) occurred in a colorectal cancer patient after restarting irinotecan and bevacizumab (a VEGF inhibitor). This is the first reported case of dysphonia linked to bevacizumab rechallenge.
Area of Science:
- Oncology
- Pharmacology
- Vascular Biology
Background:
- Vascular Endothelial Growth Factor (VEGF) signaling drives tumor angiogenesis, making its inhibition a strategy to slow cancer growth.
- Bevacizumab, a monoclonal antibody targeting VEGF, is used with chemotherapy (e.g., irinotecan) for advanced colorectal cancer.
- Antiangiogenic therapies, including bevacizumab, can affect normal vasculature, with dysphonia anecdotally reported.
Observation:
- A 60-year-old male with metastatic colorectal cancer experienced severe dysphonia.
- The voice changes occurred after the patient was reintroduced to a treatment regimen of irinotecan and bevacizumab.
Findings:
- This case report details the first known instance of dysphonia associated with bevacizumab rechallenge.
- The findings suggest a potential link between re-administering bevacizumab and the development of severe voice alterations.
Implications:
- Clinicians should be aware of potential vocal side effects when reintroducing bevacizumab in cancer patients.
- Further investigation is warranted to understand the mechanism linking bevacizumab rechallenge to dysphonia.
- This highlights the importance of monitoring for and reporting adverse events, even anecdotally reported ones, during cancer therapy.
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