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Related Experiment Videos

[Filaggrin].

Y Sarret1, A Reano, J Kanitakis

  • 1Laboratoire de Recherche Dermatologique et Immunologie, INSERM U.209, CNRS UA 601, Hôpital Edouard Herriot, Lyon, France.

Pathologie-Biologie
|April 1, 1989
PubMed
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Histidine-rich proteins, known as filaggrin, are crucial for skin barrier formation. They aggregate with keratin to build the stratum corneum and maintain skin hydration.

Area of Science:

  • Biochemistry
  • Dermatology
  • Cell Biology

Background:

  • Mammalian epidermis contains keratohyalin granules in the granular layer.
  • These granules contain a unique, histidine-rich protein with high molecular weight and basic amino acids.

Purpose of the Study:

  • To investigate the role of histidine-rich proteins in epidermal differentiation and stratum corneum formation.
  • To elucidate the structure and function of filaggrin and its precursor, profilaggrin.

Main Methods:

  • Analysis of protein modifications during terminal differentiation.
  • In vitro studies of protein interactions with keratin intermediate filaments.
  • Examination of epidermal diseases and cell cultures.

Main Results:

Related Experiment Videos

  • A high molecular weight histidine-rich protein (profilaggrin) is dephosphorylated and proteolyzed into filaggrin during differentiation.
  • Filaggrin forms ordered macrofibrils with keratin, resembling the stratum corneum structure.
  • Filaggrin contributes to skin hydration by generating free amino acids.

Conclusions:

  • Filaggrin plays a dual role in forming the stratum corneum matrix and maintaining skin hydration.
  • The histidine-rich protein pathway is integral to epidermal keratinization and differentiation.
  • Understanding filaggrin is key to comprehending epidermal diseases.