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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Irritable Bowel Syndrome I: Introduction01:17

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
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Structural brain lesions in inflammatory bowel disease.

Can Dolapcioglu1, Hatice Dolapcioglu1

  • 1Can Dolapcioglu, Department of Gastroenterology, Dr. Lutfi Kirdar Kartal Research and Training Hospital, 34890 Istanbul, Turkey.

World Journal of Gastrointestinal Pathophysiology
|November 25, 2015
PubMed
Summary

Inflammatory bowel disease (IBD) can cause central nervous system (CNS) complications, including brain lesions. Understanding these CNS manifestations is crucial for early diagnosis and improved patient care.

Keywords:
Brain lesionsCrohn’s diseaseInflammatory bowel diseaseMagnetic resonance imagingStructural lesionsUlcerative colitis

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Area of Science:

  • Neurology
  • Gastroenterology
  • Radiology

Background:

  • Central nervous system (CNS) complications in inflammatory bowel disease (IBD) require attention for timely diagnosis and treatment.
  • Unexplained neurological manifestations may indicate underlying pathogenic mechanisms in IBD.

Purpose of the Study:

  • To review symptomatic and asymptomatic brain lesions in IBD patients detectable by imaging.
  • To explore the frequency and potential mechanisms of these CNS manifestations.

Main Methods:

  • Literature review focusing on CNS complications in inflammatory bowel disease.
  • Analysis of imaging studies to identify brain lesions.
  • Discussion of proposed pathogenic mechanisms.

Main Results:

  • A direct causal link between IBD and asymptomatic brain changes is not established, but proposed mechanisms include vasculitis, thromboembolism, and malnutrition.
  • Cerebrovascular thromboembolism is the most frequent and severe CNS complication of IBD.
  • Other CNS manifestations include vasculitis, demyelinating conditions, CNS infections, and risks associated with biological agents.

Conclusions:

  • Further research into the nature and mechanisms of IBD-associated brain lesions can enhance patient care through early detection and treatment.
  • Identifying CNS manifestations in IBD is vital for understanding the disease and improving therapeutic strategies.