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Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe.

Derek Nankivil1, Gar Waterman1, Francesco LaRocca1

  • 1Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA.

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Summary

This study introduces the first handheld swept source optical coherence tomography (SSOCT) system for rapid, sequential imaging of both anterior and posterior eye segments. The compact device offers high resolution and sensitivity for comprehensive ophthalmic diagnostics.

Keywords:
(080.3620) Lens system design(110.4500) Optical coherence tomography(170.0110) Imaging systems(170.4460) Ophthalmic optics and devices(170.4470) Ophthalmology(170.5755) Retina scanning

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Area of Science:

  • Ophthalmic imaging
  • Biomedical optics
  • Medical device engineering

Background:

  • Current ophthalmic imaging often requires separate devices for anterior and posterior segments.
  • Handheld devices offer potential for increased patient comfort and accessibility.
  • Swept Source Optical Coherence Tomography (SSOCT) provides high-resolution cross-sectional imaging of biological tissues.

Purpose of the Study:

  • To develop and characterize the first handheld SSOCT system capable of rapidly imaging both anterior and posterior eye segments.
  • To evaluate the system's performance metrics, including resolution, sensitivity, and field of view for both imaging modes.
  • To demonstrate the system's utility in healthy volunteers.

Main Methods:

  • A single 2D microelectromechanical systems (MEMS) scanner was employed for both anterior and posterior imaging modes.
  • Custom and commercial optics were optimized for each imaging application.
  • A bi-stable rotary solenoid actuated fold mirror assembly switched between imaging modes.
  • A miniature motorized translation stage corrected for patient refractive error.

Main Results:

  • The handheld SSOCT system achieved axial resolution of 8 μm and lateral resolutions of 9 μm (posterior) and 24 μm (anterior).
  • Imaging depth ranges of 7.4 mm and peak sensitivities of 103 dB (posterior) and 99 dB (anterior) were achieved.
  • The system features a working distance of 26.1 mm, a wide field of view, and a compact, lightweight design (<630 g).
  • Refractive error correction from -12.6 to +9.9 D was integrated.

Conclusions:

  • The developed handheld SSOCT system enables rapid, sequential imaging of both eye segments with high performance.
  • This integrated system represents a significant advancement in ophthalmic diagnostic tools.
  • The compact and versatile design holds promise for improved clinical ophthalmic examinations.