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Differences in Mouse Hepatic Thyroid Hormone Transporter Expression with Age and Hyperthyroidism.

Kathrin Engels1, Helena Rakov1, Denise Zwanziger1

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Summary
This summary is machine-generated.

Aging alters thyroid hormone (TH) transporter expression in mouse liver. These changes, observed in both normal and hyperthyroid states, may explain age-related variations in TH action.

Keywords:
AgingHyperthyroidismLiverThyroid

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Gerontology

Background:

  • Thyroid dysfunction symptoms vary with age, often presenting subtly in the elderly.
  • This suggests age influences thyroid hormone (TH) action, potentially through altered TH production, metabolism, or target organ response.

Purpose of the Study:

  • To investigate age-dependent changes in TH transporter expression in liver tissue.
  • To understand the role of liver TH transporters in age-related variations of TH action.

Main Methods:

  • Induced chronic hyperthyroidism in young (4-month) and old (20-month) male mice using L-thyroxine (T4).
  • Analyzed TH transporter and TH-responsive gene expression in liver RNA.
  • Measured serum TH concentrations.

Main Results:

  • Older mice had higher baseline serum free T4 (fT4) than younger mice.
  • Hyperthyroidism normalized serum T4 and fT4 levels in both age groups.
  • Euthyroid older mice showed higher TH transporter expression, except for Mct8 and Oatp1a1.
  • Hyperthyroidism downregulated Oatp1a1, Oatp1b2, and Oatp1a4, and upregulated Mct10, Lat1, and Lat2 in liver, with this pattern consistent in older mice.

Conclusions:

  • Demonstrated age-dependent differences in liver TH transporter mRNA expression in mice.
  • These age-related changes occur in both euthyroid and hyperthyroid conditions.
  • Highlights the liver's role as a TH target organ affected by age and transporter expression.