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    Area of Science:

    • Medicinal Chemistry
    • Radiation Physics
    • Organic Synthesis

    Background:

    • Mannich bases are a class of organic compounds with diverse biological activities.
    • Understanding radiation interaction is crucial for developing radiopharmaceuticals and assessing safety.
    • Previous research has explored the synthesis and bioactivity of Mannich bases, but their radiation parameters are less studied.

    Purpose of the Study:

    • To synthesize novel 1-Aryl-3-dibenzylamino-propane-1-on hydrochloride Mannich bases.
    • To experimentally and theoretically determine the radiation parameters of these synthesized compounds.
    • To evaluate the potential of these compounds as anti-cancer drug candidates based on their radiation interaction properties.

    Main Methods:

    • Classical conventional heating method was employed for the synthesis of Mannich bases with varying aryl substituents.
    • Mass attenuation coefficient (μm), effective atomic number (Z(eff)), and effective electron density (N(el)) were measured using an HPGe detector across a range of photon energies (8.040–59.54 keV).
    • Theoretical calculations were performed to complement experimental radiation parameter determination.

    Main Results:

    • The synthesized Mannich bases included derivatives with phenyl, 4-methylphenyl, 4-fluorophenyl, 4-nitrophenyl, 4-chlorophenyl, 4-bromophenyl, and 2-thienyl groups.
    • Radiation parameters such as mass attenuation coefficient, effective atomic number, and effective electron density were successfully determined.
    • A key finding indicated that the phenyl ring exhibits radiation absorption characteristics similar to the thiophene ring.

    Conclusions:

    • The study successfully synthesized and characterized novel Mannich bases.
    • The determined radiation parameters provide valuable data for assessing the suitability of these compounds in medical applications, particularly in oncology.
    • The observed similarity in radiation absorption between phenyl and thiophene rings offers insights for future drug design in anti-cancer therapies.