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Transnasal endoscopic microfractured fat injection in glottic insufficiency
B-ENT
|November 26, 2015
Summary
A novel treatment for glottic insufficiency, Microfractured Fat Fibre-endoscopic Injection (MFFI), showed promising results in a small study. This outpatient procedure using autologous fat improved voice in all patients without complications.
Area of Science:
- Regenerative Medicine
- Otolaryngology
- Vocal Cord Surgery
Background:
- Glottic insufficiency, often caused by vocal cord palsy, significantly impacts voice quality and quality of life.
- Current treatments for glottic insufficiency have limitations, including invasiveness and potential complications.
Observation:
- A novel technique, Microfractured Fat Fibre-endoscopic Injection (MFFI), was evaluated for glottic insufficiency.
- The procedure involved injecting processed autologous adipose tissue via a flexible endoscope under local anesthesia.
- The Lipogems device was used for adipose tissue processing, ensuring purity, fluidity, and mesenchymal stem cell content.
Findings:
- MFFI was well-tolerated in three patients with vocal cord palsy, with no observed complications.
- All patients demonstrated consistent voice improvement over a 12-month follow-up period.
- The observed voice improvement suggests a potential stem cell-related regenerative effect.
Implications:
- MFFI presents a straightforward and efficacious outpatient treatment option for glottic insufficiency.
- This innovative technique combines advantages of existing treatments while utilizing only autologous material.
- MFFI holds potential as a valuable tool in managing vocal cord dysfunction.
