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Related Concept Videos

Skin Cancer01:30

Skin Cancer

6.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Related Experiment Video

Updated: Mar 29, 2026

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
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Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

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Methods of Melanoma Detection.

Sancy A Leachman1, Pamela B Cassidy2, Suephy C Chen3

  • 1Department of Dermatology and Knight Cancer Institute, Oregon Health and Science University, 3303 SW Bond Avenue, CH16D, Portland, OR, 97239, USA. leachmas@ohsu.edu.

Cancer Treatment and Research
|November 26, 2015
PubMed
Summary

Early detection of melanoma significantly improves survival. This chapter reviews current and emerging melanoma detection methods, including imaging, optical biopsy, and molecular assays, to reduce mortality.

Keywords:
Atypical neviDermoscopyFluorescence in situ hybridization (FISH)Gene expression profilingHyperspectral imagingIn vivo confocal microscopyMelanoma detectionMelanoma digital photographyMelanoma preventionMelanoma screeningOptical biopsyOptical coherence tomographyQuantitative real-time PCR (qRT-PCR)

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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Area of Science:

  • Dermatology
  • Oncology
  • Medical Imaging

Background:

  • Melanoma detection and removal before metastasis are critical for improving patient prognosis and survival rates.
  • Current detection strategies involve public education, screening programs, and advanced imaging technologies.

Purpose of the Study:

  • To summarize existing methods for melanoma detection.
  • To review cutting-edge technologies for melanoma detection with the potential to decrease mortality.

Main Methods:

  • Review of educational campaigns and screening examinations for at-risk individuals.
  • Comparison of standard and advanced photographic techniques for melanoma detection.
  • Evaluation of magnifying devices, algorithms, in vivo confocal microscopy, and optical biopsy technologies.
  • Discussion of cellular and molecular diagnostic methods like comparative genomic hybridization (CGH), fluorescent in situ hybridization (FISH), and quantitative reverse transcriptase polymerase chain reaction (qRT-PCR).

Main Results:

  • The chapter provides a comprehensive overview of current and emerging melanoma detection tools.
  • It compares the efficacy and application of various imaging and molecular diagnostic techniques.
  • The potential impact of noninvasive methods like optical biopsy is discussed in relation to traditional tissue biopsy.

Conclusions:

  • Early and accurate melanoma detection is paramount for effective treatment and improved survival outcomes.
  • Advancements in imaging and molecular diagnostics offer promising avenues for reducing melanoma-related mortality.
  • Integrating novel technologies into clinical practice can enhance diagnostic accuracy and patient care.