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Neurocognitive functioning as an intermediary variable between psychopathology and insight in schizophrenia
Samuel Suk-Hyun Hwang1, Yong Min Ahn2, Yong Sik Kim3
1Department Psychology, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju, 500-757, Korea.
Psychiatry Research
|November 26, 2015
Summary
This study explored how neurocognitive deficits impact insight in schizophrenia. Findings suggest a weak and selective link, with perseverative responses partially mediating the relationship between symptoms and insight.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- Insight is crucial for schizophrenia treatment adherence.
- Neuropsychological deficits are implicated in impaired insight.
Purpose of the Study:
- To investigate neurocognitive measures as intermediaries between psychopathology and insight in schizophrenia.
- To construct and test prediction models for insight in acute schizophrenia patients.
Main Methods:
- Fifty-six acute schizophrenia patients completed symptom (Positive and Negative Syndrome Scale) and neurocognitive assessments at baseline, 8 weeks, and 1 year.
- Exploratory prediction models were built using neurocognitive measures (K-WAIS, COWAT, CPT) as intermediaries.
Main Results:
- Perseverative response (COWAT) showed a partial mediating effect on insight, both cross-sectionally and longitudinally.
- Other neurocognitive measures (K-WAIS picture arrangement, CPT standard error) correlated with symptoms and insight but did not mediate the relationship.
- The overall relationship between neurocognitive functioning and insight was selective and weak.
Conclusions:
- Neurocognitive deficits play a selective and limited role in mediating insight in schizophrenia.
- Perseverative response is a potential, albeit weak, neurocognitive marker associated with insight in schizophrenia.
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