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Metastatic saccrococcygeal chordoma
Mostafa Fatehi Hassanabad1, Alireza Mansouri2, Naif M Alotaibi2
1Division of Neurosurgery, University of British Columbia, Vancouver, Canada.
Summary
Brain metastases from sacrococcygeal chordoma are rare, with only eight cases reported. Despite aggressive treatments, including novel strategies, outcomes for these patients remain poor, highlighting a significant unmet need in chordoma treatment.
Area of Science:
- Neuro-oncology
- Orthopedic Oncology
- Surgical Pathology
Background:
- Sacrococcygeal chordomas are rare, locally invasive notochord-related sarcomas.
- Brain metastasis from sacrococcygeal chordoma is exceptionally rare, with limited case reports.
Observation:
- A 46-year-old male with a history of sacral chordoma presented with worsening headaches and left-sided hemiplegia.
- Cerebral MRI revealed multiple enhancing lesions, consistent with metastatic chordoma upon resection and histopathological analysis.
Findings:
- This case represents the ninth reported instance of brain metastasis from a sacrococcygeal chordoma.
- Standard adjuvant radiotherapy and chemotherapy regimens showed limited efficacy.
- Novel therapeutic strategies investigated in this case also yielded disappointing results.
Implications:
- The rarity and aggressive nature of chordoma brain metastases pose significant challenges for effective treatment.
- Current therapeutic approaches offer limited success, underscoring the need for innovative treatment strategies.
- Further research into targeted therapies is crucial for improving outcomes in patients with chordoma brain metastases.
