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In vitro activity of ceftaroline against staphylococci from prosthetic joint infection

Kyung-Hwa Park1, Kerryl E Greenwood-Quaintance2, Robin Patel3

  • 1Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, South Korea.

Diagnostic Microbiology and Infectious Disease
|November 26, 2015
PubMed

Insights

Ceftaroline effectively inhibited all staphylococci, including methicillin-resistant strains, in vitro. This suggests ceftaroline

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Prosthetic joint infections (PJIs) are often caused by Staphylococcus species.
  • Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) pose significant treatment challenges.
  • Novel antimicrobial agents are needed for effective PJI management.

Purpose of the Study:

  • To evaluate the in vitro activity of ceftaroline against staphylococci isolated from patients with PJIs.
  • To determine the susceptibility of both methicillin-susceptible and methicillin-resistant staphylococcal strains to ceftaroline.

Main Methods:

  • Etest method was employed to determine the minimum inhibitory concentrations (MICs) of ceftaroline.
  • Staphylococcal isolates were recovered from patients diagnosed with prosthetic joint infections.
  • Isolates included Staphylococcus aureus and Staphylococcus epidermidis, with varying oxacillin resistance profiles.

Main Results:

  • Ceftaroline demonstrated potent in vitro activity against all tested staphylococcal isolates, inhibiting growth at concentrations ≤0.5 μg/mL.
  • MIC(90/50) values for ceftaroline ranged from 0.094/0.047 μg/mL (methicillin-susceptible S. epidermidis) to 0.5/0.38 μg/mL (methicillin-resistant S. aureus).
  • All isolates, including MRSA and MRSE, were susceptible to ceftaroline at clinically relevant concentrations.

Conclusions:

  • Ceftaroline exhibits significant in vitro efficacy against a broad spectrum of staphylococci implicated in PJIs.
  • These findings support the further investigation of ceftaroline as a therapeutic agent for staphylococcal PJIs.
  • Ceftaroline represents a promising option for treating infections caused by both methicillin-susceptible and methicillin-resistant staphylococci.
Keywords:
CeftarolineProsthetic joint infectionStaphylococcus aureusStaphylococcus epidermidis

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