Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

1.2K
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Converting negative symptom dimension scores across SANS and PANSS.

Schizophrenia research·2026
Same author

Sensorimotor recovery and neuropathic pain reduction after remotely delivered cognitive multisensory rehabilitation or remotely delivered exercise in adults with spinal cord injury: a pilot clinical trial.

medRxiv : the preprint server for health sciences·2026
Same author

Linking electric field pattern to clinical efficacy of transcranial electrical stimulation in substance use disorder: A modeling-based meta-analysis.

Neuroscience and biobehavioral reviews·2026
Same author

Greater sustained sensorimotor function recovery and neuropathic pain reduction with Cognitive Multisensory Rehabilitation compared to adaptive fitness in adults with spinal cord injury: a pilot clinical trial.

medRxiv : the preprint server for health sciences·2026
Same author

Preliminary efficacy of cognitive multisensory rehabilitation for neuropathic pain in chronic spinal cord injury: a phase I randomized controlled trial.

Scientific reports·2026
Same author

Personal causal modeling of affect and eating behaviors in bulimia nervosa: implications for personalized treatment.

Journal of eating disorders·2026

Related Experiment Video

Updated: Mar 29, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.1K

Longitudinal changes in white matter microstructure after heavy cannabis use.

Mary P Becker1, Paul F Collins1, Kelvin O Lim2

  • 1Department of Psychology, University of Minnesota, 75 East River Road, Minneapolis, MN 55455, United States; Center for Neurobehavioral Development, University of Minnesota, 717 Delaware Street SE, Ste. 333, Minneapolis, MN 55414, United States.

Developmental Cognitive Neuroscience
|November 26, 2015
PubMed
Summary

This study reveals that continued cannabis use in young adults impairs white matter development, affecting brain structure and verbal learning. These findings highlight the long-term neurological impact of adolescent cannabis consumption.

Keywords:
CannabisDTILongitudinalWhite matterYoung adult

More Related Videos

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
06:09

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Published on: May 30, 2025

909
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Related Experiment Videos

Last Updated: Mar 29, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.1K
Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates
06:09

Development of a Preclinical Inhalation Model to Test Vaporized Cannabis Distillates

Published on: May 30, 2025

909
Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice
07:51

Administration of Δ9-Tetrahydrocannabinol (THC) in Adolescent and Adult Mice

Published on: August 1, 2025

1.2K

Area of Science:

  • Neuroscience
  • Neuroimaging
  • Addiction Research

Background:

  • Cross-sectional studies suggest cannabis use alters brain white matter microstructure.
  • The developmental etiology of these alterations remains unclear.
  • Longitudinal data is needed to understand the impact of cannabis on developing brains.

Purpose of the Study:

  • To investigate the longitudinal effects of regular cannabis use on white matter microstructure development in young adults.
  • To examine the relationship between the amount of cannabis use and white matter changes.
  • To assess the association between white matter alterations and cognitive function.

Main Methods:

  • Longitudinal voxelwise analyses of Diffusion Tensor Imaging (DTI) data.
  • Comparison between 23 young adult regular cannabis users and 23 matched controls.
  • Data collected at baseline and a 2-year follow-up.

Main Results:

  • Cannabis users showed reduced longitudinal growth in fractional anisotropy (FA) in key white matter tracts, including the superior longitudinal fasciculus and corticospinal tract.
  • Reduced longitudinal reduction of radial diffusion was observed in several white matter regions in cannabis users.
  • Higher cannabis consumption correlated with reduced FA longitudinal growth and poorer verbal learning performance.

Conclusions:

  • Continued heavy cannabis use during adolescence and young adulthood disrupts ongoing white matter development.
  • These microstructural alterations are associated with functional impairments, specifically in verbal learning.
  • Findings underscore the neurodevelopmental risks associated with adolescent cannabis use.