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Updated: Mar 29, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
Published on: December 1, 2023
Effect of cataract surgery on regulation of circadian rhythms
Jesper Høiberg Erichsen1, Adam E Brøndsted1, Line Kessel1
1From the Faculty of Health and Medical Sciences (Erichsen), University of Copenhagen, Copenhagen, Department of Ophthalmology (Erichsen, Brøndsted), Glostrup Hospital, Glostrup, and Department of Ophthalmology (Kessel), Roskilde Hospital, Roskilde, Denmark.
Unlabelled:
This review looked at the effect of cataract surgery on the regulation of circadian rhythms and compared the effect of blue light-filtering and clear intraocular lenses (IOLs) on circadian rhythms. A systematic review and metaanalysis were performed, and the level of evidence was evaluated based on the principles described in the Grading of Recommendations Assessment, Development, and Evaluation system. A literature search of PubMed, Embase, and Cochrane Library databases was performed, as well as a search for unpublished trials at the U.S. National Institutes of Health Clinical Trials web site. Trials that reported the effect of cataract surgery on circadian rhythms were included. Outcomes were the Pittsburgh Sleep Quality Index (PSQI) global score, number of poor sleepers, Epworth Sleepiness Score, sleep efficiency, and mean concentration of melatonin. Cataract surgery improved regulation of circadian rhythms measured by the PSQI questionnaire, but the clinical relevance is uncertain. There was no difference between the effect of the 2 IOL types.
Financial Disclosure:
No author has a financial or proprietary interest in any material or method mentioned.
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