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Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent energy restriction and weight loss: a systematic review.

C S Davis1, R E Clarke1, S N Coulter1

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Summary

Intermittent energy restriction (IER) leads to significant weight loss in overweight and obese adults. This eating pattern is as effective as daily energy restriction (DER) for weight management.

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Area of Science:

  • Nutrition science
  • Obesity research
  • Dietary interventions

Background:

  • Intermittent energy restriction (IER) is an eating pattern involving cycles of restricted and unrestricted calorie intake.
  • IER is emerging as a popular alternative to daily energy restriction (DER) for weight loss.
  • Overweight and obesity are significant global health concerns requiring effective management strategies.

Purpose of the Study:

  • To systematically review the effectiveness of IER for weight loss in overweight and obese adults.
  • To compare the weight loss efficacy of IER against DER.
  • To evaluate the impact of IER on body composition.

Main Methods:

  • A systematic literature search was performed across multiple databases (CINAHL, Embase, Medline, PsycINFO, Cochrane, Scopus).
  • Eight studies comparing IER interventions with DER control groups in overweight or obese adults were included.
  • Data on weight loss and body composition changes were extracted and analyzed.

Main Results:

  • All included studies reported significant weight loss in participants following IER.
  • Average weekly weight loss ranged from 0.2 to 0.8 kg.
  • IER demonstrated comparable weight loss to DER when overall calorie deficits were similar, with similar effects on fat mass, fat-free mass, and waist circumference.

Conclusions:

  • IER is an effective strategy for achieving weight loss in overweight and obese individuals.
  • The weight loss achieved through IER is comparable to that of DER.
  • IER presents a viable alternative weight loss approach for healthcare providers to consider for specific patient populations.