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Hypofractionated whole breast radiotherapy: current perspectives.

Theodora A Koulis1, Tien Phan1, Ivo A Olivotto1

  • 1Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, AB, Canada.

Breast Cancer (Dove Medical Press)
|November 26, 2015
PubMed
Summary

Hypofractionated radiotherapy (RT) is as effective as standard RT for breast cancer, offering better convenience and outcomes. This review suggests hypofractionation should become the new standard for adjuvant breast cancer treatment.

Keywords:
breast cancercosmesisfractionationradiotherapy

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Area of Science:

  • Oncology
  • Radiotherapy
  • Breast Cancer Treatment

Background:

  • Adjuvant radiotherapy (RT) is crucial in breast cancer management, with variable dose and fractionation schedules.
  • The traditional
  • standard
  • adjuvant RT prescription is 50 Gy in 25 fractions over 5 weeks.
  • Hypofractionated regimens offer an alternative approach.

Purpose of the Study:

  • To review indications for whole breast hypofractionated adjuvant RT after breast-conserving surgery.
  • To propose hypofractionation as the new standard for adjuvant breast cancer RT.

Main Methods:

  • Review of current literature on adjuvant breast cancer radiotherapy fractionation schedules.
  • Analysis of efficacy, cosmetic, and normal tissue outcomes of hypofractionated RT.

Main Results:

  • Hypofractionated regimes (e.g., 42.5 Gy/16 fractions, 40 Gy/15 fractions) are equally effective as standard RT.
  • These regimes achieve similar or better cosmetic and normal tissue outcomes for invasive and in situ breast cancer.
  • Hypofractionation offers increased patient convenience and reduced costs.

Conclusions:

  • Hypofractionated adjuvant RT is a safe and effective option for breast cancer patients post-breast-conserving surgery.
  • Consideration of extended fractionation may be beneficial for high-risk patients.
  • Hypofractionation should be considered the new standard for adjuvant breast cancer RT.