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Pharmacological perspectives in sarcopenia: a potential role for renin-angiotensin system blockers?
Laura Sartiani1, Valentina Spinelli1, Annunziatina Laurino1
1Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), Center of Molecular Medicine (CIMMBA), University of Florence, Florence, Italy.
Abstract:
Sarcopenia represents a major health problem highly prevalent in elderly and age-related chronic diseases. Current pharmacological strategies available to prevent and reverse sarcopenia are largely unsatisfactory thus raising the need to identify novel targets for pharmacological intervention and possibly more effective and safe drugs. This review highlights the current knowledge of the potential benefits of renin-angiotensin system blockade in sarcopenia and discuss the main mechanisms underlying the effects.
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