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Updated: Mar 29, 2026
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Published on: January 21, 2020
Periodontal disease in Paget's disease of bone
1Odontostomathologic Unit, Policlinico "Le Scotte" University of Siena, Siena, Italy.
Abstract:
A 59-year-old man suffering from Paget's disease of bone and periodontal disease was examined in anticipation of bisphosphonate treatment. The previous therapy with clodronate resulted ineffective and markers of bone turnover were markedly elevated. Periodontal disease was correctly approached and treated with an excellent outcome. 5 mg zoledronate iv infusion induced a remarkable reduction of bone markers which persisted on time within the normal range. After zoledronate treatment no signs of osteonecrosis of the jaw (ONJ) were observed. A correct management of periodontal disease is mandatory in pagetic patients on bisphosphonate treatment.
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