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Related Concept Videos

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Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
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Updated: Mar 29, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Bioabsorbable polymers in cancer therapy: latest developments.

Ana C Fonseca1, Arménio C Serra1, Jorge F J Coelho1

  • 1CEMUC, Department of Chemical Engineering, University of Coimbra, Rua Sílvio Lima-Pólo II, 3030-790 Coimbra, Portugal.

The EPMA Journal
|November 26, 2015
PubMed
Summary
This summary is machine-generated.

Bioabsorbable polymers are emerging as advanced drug delivery systems (DDS) for cancer therapy. These materials offer targeted delivery, minimizing chemotherapy side effects on healthy cells.

Keywords:
Bioabsorbable polymersCancerImplantsMicellesNanoparticles

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Area of Science:

  • Biomaterials Science
  • Oncology
  • Drug Delivery Systems

Background:

  • Cancer remains a leading cause of global mortality.
  • Chemotherapy often lacks specificity, leading to severe side effects on healthy tissues.
  • Targeted drug delivery systems (DDS) are crucial for improving cancer treatment efficacy and patient outcomes.

Purpose of the Study:

  • To review recent advancements in bioabsorbable polymers utilized as DDS in cancer therapy.
  • To highlight the application of these polymers in nanoparticles, micelles, and implants for targeted cancer treatment.

Main Methods:

  • Literature review focusing on bioabsorbable polymers in cancer drug delivery.
  • Analysis of studies employing nanoparticles, micelles, and implants for targeted cancer therapy.
  • Synthesis of recent developments and trends in the field.

Main Results:

  • Bioabsorbable polymers demonstrate significant potential as versatile materials for DDS.
  • These polymers can be engineered into various forms like nanoparticles, micelles, and implants for controlled drug release.
  • Targeted delivery using these DDS can effectively mitigate side effects associated with conventional chemotherapy.

Conclusions:

  • Bioabsorbable polymers represent a promising strategy for developing advanced DDS in oncology.
  • Further research into these materials can lead to more effective and less toxic cancer therapies.
  • Nanoparticles, micelles, and implants made from bioabsorbable polymers are key areas for future development in cancer treatment.