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The Acute Effect of Hemodialysis on Choroidal Thickness

Osman Çelikay1, Sinan Çalışkan1, Tolga Biçer1

  • 1Ophthalmology Department, Dışkapi Yildirim Beyazit Training and Research Hospital, 06070 Ankara, Turkey.

Journal of Ophthalmology
|November 26, 2015
PubMed

Insights

Hemodialysis (HD) significantly reduces choroidal thickness (CT) in patients with end-stage renal disease (ESRD). Changes in CT after HD correlate with alterations in diastolic blood pressure.

Area of Science:

  • Ophthalmology
  • Nephrology
  • Cardiovascular Science

Background:

  • End-stage renal disease (ESRD) affects multiple organ systems.
  • Ocular changes can occur in patients with ESRD undergoing hemodialysis (HD).
  • Choroidal thickness (CT) is a potential indicator of ocular health.

Purpose of the Study:

  • To investigate the impact of hemodialysis (HD) on choroidal thickness (CT).
  • To explore the relationship between HD, CT, and systemic blood pressure in ESRD patients.

Main Methods:

  • Optical coherence tomography (OCT) was used to measure CT in 41 ESRD patients before and after HD.
  • Intraocular pressure (IOP), blood pressure, and body weight were also recorded.
  • Statistical analysis, including stepwise multivariate linear regression, was performed.

Main Results:

  • Mean subfoveal choroidal thickness (SFCT) significantly decreased post-HD (p < 0.001).
  • CT in temporal and nasal regions also showed significant reduction (p < 0.001).
  • Diastolic blood pressure changes best explained the observed variations in CT (r = 0.327, p = 0.040).

Conclusions:

  • Hemodialysis leads to a significant decrease in choroidal thickness in ESRD patients.
  • The observed changes in CT following HD may be linked to alterations in systemic blood pressure.

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