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Case Report Associated with Aspergillosis and Hepatitis E Virus Coinfection in Himalayan Griffons

Heng Li1, Rining Zhu1, Ruiping She1

  • 1Laboratory of Veterinary Pathology and Public Health, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

Biomed Research International
|November 26, 2015
PubMed

Insights

Four Himalayan griffons died from concurrent infections with Aspergillus fungus and Hepatitis E virus (HEV). This study details the pathological findings and pathogen identification in these rare avian deaths.

Area of Science:

  • Veterinary Pathology
  • Avian Medicine
  • Mycology
  • Virology

Background:

  • Himalayan griffons are rare avian species.
  • Concurrent infections can complicate diagnosis and treatment in avian species.
  • Hepatitis E virus (HEV) and Aspergillus infections are known avian pathogens.

Purpose of the Study:

  • To identify the causes of death in four Himalayan griffons from Beijing Zoo.
  • To characterize the pathological changes associated with the identified pathogens.
  • To report the first known co-infection of Aspergillosis and HEV in this species.

Main Methods:

  • Necropsy and histopathological examination of tissues.
  • Polymerase Chain Reaction (PCR) for pathogen identification.
  • 18S rRNA gene sequencing for fungal identification.

Main Results:

  • Severe pathological changes observed, including splenic necrosis and kidney fungal nodules.
  • PCR confirmed the presence of Aspergillus in all four griffons.
  • HEV was also detected in all affected birds.
  • Concurrent Aspergillosis and HEV infection identified.

Conclusions:

  • Aspergillosis and Hepatitis E virus co-infection led to the deaths of four Himalayan griffons.
  • This is the first documented case of concurrent Aspergillosis and HEV in this rare avian species.
  • Highlights the importance of comprehensive diagnostic approaches in avian mortality cases.

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