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Updated: Mar 29, 2026

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
Published on: December 8, 2023
Complement component 3: a new paradigm in tuberculosis vaccine
José De La Fuente1,2, Christian Gortázar1, Ramón Juste3
1a SaBio, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM) , Ciudad Real , Spain.
Abstract:
Vaccines are critical for the control of tuberculosis (TB) affecting humans and animals worldwide. First-generation vaccines protect from active TB but new vaccines are required to protect against pulmonary disease and infection. Recent advances in post-genomics technologies have allowed the characterization of host-pathogen interactions to discover new protective antigens and mechanisms to develop more effective vaccines against TB. Studies in the wild boar model resulted in the identification of complement component 3 (C3) as a natural correlate of protection against TB. Oral immunization with heat-inactivated mycobacteria protected wild boar against TB and showed that C3 plays a central role in protection. These results point at C3 as a target to develop novel vaccine formulations for more effective protection against TB in humans and animals.
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