Related Experiment Video

Updated: Mar 29, 2026

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
03:47

Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography

Published on: November 1, 2024

439

Helicobacter pylori infection in children with portal hypertensive gastropathy

Ayman E Eskander1, Bahaa I Mounir2, Carolyne Morcos Ghobrial1

  • 1Department of Pediatrics, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.

Minerva Pediatrica
|November 26, 2015
PubMed

Insights

Helicobacter pylori (H. pylori) infection is not more common in children with portal hypertensive gastropathy (PHG). However, H. pylori may worsen PHG severity and contribute to growth retardation and iron deficiency.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Infectious Diseases

Background:

  • Limited data exists on the association between Helicobacter pylori (H. pylori) and portal hypertensive gastropathy (PHG) in pediatric populations.
  • This study addresses the knowledge gap regarding H. pylori prevalence and its impact on PHG in children.

Purpose of the Study:

  • To investigate the prevalence of H. pylori infection in children diagnosed with PHG.
  • To explore the relationship between H. pylori infection and the severity of PHG and its clinical manifestations in children.

Main Methods:

  • Gastric mucosal biopsies from children with PHG were analyzed for H. pylori using rapid urease testing and histology.
  • Prevalence data were compared to a control group of children undergoing endoscopy for other gastrointestinal issues.

Main Results:

  • H. pylori infection prevalence was similar (~60%) in both PHG and control groups.
  • Children with PHG exhibited significantly lower height, hemoglobin, platelets, and serum iron levels.
  • Severe PHG correlated with higher-grade esophageal varices, and H. pylori infection was linked to lower hemoglobin, serum iron, and ferritin in PHG patients.

Conclusions:

  • H. pylori infection is not more prevalent in pediatric PHG but may exacerbate PHG severity.
  • A synergistic effect between PHG and H. pylori may contribute to growth retardation and iron deficiency in affected children.
Abstract

More Related Videos

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability09:05

High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability

Published on: November 21, 2014

16.2K
Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection08:24

Author Spotlight: Gastric Epithelial Cell Responses in Helicobacter pylori infection

Published on: July 5, 2024

1.2K

Related Concept Videos

Peptic Ulcer01:27

Peptic Ulcer

Peptic ulcers are erosive lesions of the gastric or duodenal lining, most commonly caused by Helicobacter pylori infection. This Gram-negative, helical bacterium has adapted to survive the stomach’s acidic environment by producing urease, which converts urea into ammonia and carbon dioxide. The ammonia neutralizes gastric acid in the bacterium’s immediate environment, allowing colonization of the gastric mucosa. H. pylori attaches to mucus-secreting epithelial cells, penetrates the...
30
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
2.1K
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
782
Pathophysiology of Peptic Ulcer Disease: Injurious Factors01:22

Pathophysiology of Peptic Ulcer Disease: Injurious Factors

Peptic ulcers are sores on the stomach's inner lining and the upper small intestine, which are the result of disruptions in the mucosal layer that houses parietal cells which produce gastric acid, and chief cells which secrete pepsinogen.
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
1.5K
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
1.0K
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.7K