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Speciation and Bioavailability Measurements of Environmental Plutonium Using Diffusion in Thin Films
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Plutonium-DTPA Model Application with USTUR Case 0269.

Kevin Konzen1, Richard Brey, Scott Miller

  • 1*Department of Nuclear Engineering and Health Physics, Idaho State University, 921 South 8th Avenue, Stop 8060, Pocatello, ID 83209-8060; †Division of Radiobiology, School of Medicine, University of Utah, Salt Lake City, UT 84108.

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Summary

A plutonium biokinetic model using DTPA was extended to a human case of plutonium inhalation. The model accurately predicted plutonium excretion and tissue burdens 38 years post-exposure.

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Area of Science:

  • Radiological Health
  • Biokinetics
  • Nuclear Medicine

Background:

  • A plutonium-diethylenetriaminepentaacetic acid (Pu-DTPA) biokinetic model was developed from wound contamination studies.
  • Human biokinetic modeling is crucial for assessing internal radiation exposure risks.

Purpose of the Study:

  • To evaluate the extension of the Pu-DTPA biokinetic model to a human case of acute plutonium nitrate inhalation (USTUR Case 0269).
  • To assess the model's predictive capability for long-term plutonium bioassay and tissue burdens.

Main Methods:

  • The Pu-DTPA model was integrated with established plutonium systemic models (ICRP Publication 67 and a modification).
  • Model predictions were compared against longitudinal urine and fecal bioassay data and final tissue plutonium content from USTUR Case 0269.
  • Chelation therapy (Ca-EDTA and Ca-DTPA) timing and administration were considered.

Main Results:

  • The integrated Pu-DTPA model successfully predicted urine and fecal bioassay results over several years post-intake.
  • The model accurately estimated the final plutonium tissue quantity measured 38 years after the inhalation exposure.

Conclusions:

  • The extended Pu-DTPA biokinetic model is a valuable tool for predicting the long-term behavior of inhaled plutonium in humans.
  • This modeling approach aids in retrospective dose assessment and understanding plutonium biokinetics in occupationally exposed individuals.