Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell membrane and volume changes during red cell development and aging.

N Mohandas1, W Groner

  • 1Department of Laboratory Medicine, University of California, San Francisco 94143-0128.

Annals of the New York Academy of Sciences
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Red cell membrane disorders.

International journal of laboratory hematology·2017
Same author

Management of infected pancreatic necrosis-the "step up" approach and minimal access retroperitoneal pancreatic necrosectomy.

The Indian journal of surgery·2015
Same author

Primary hematopoietic cells from DBA patients with mutations in RPL11 and RPS19 genes exhibit distinct erythroid phenotype in vitro.

Cell death & disease·2012
Same author

Novel aspects of Kindlin-3 function in humans based on a new case of leukocyte adhesion deficiency III.

Journal of thrombosis and haemostasis : JTH·2012
Same author

Red cell membrane and malaria.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2010
Same author

Diamond-Blackfan anemia, ribosome and erythropoiesis.

Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2010
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Red blood cell development involves critical membrane and volume changes, driven by cytoskeletal remodeling. While aging involves surface area loss and immunoglobulin binding, the exact trigger for removing old red blood cells remains unknown.

Area of Science:

  • Hematology
  • Cell Biology
  • Membrane Biophysics

Background:

  • Red blood cells (RBCs) undergo significant transformations from precursor cells to mature circulating cells.
  • Cellular volume and membrane properties are crucial for RBC function and lifespan.
  • Understanding these changes is key to comprehending RBC development and aging.

Purpose of the Study:

  • To summarize current knowledge on cell membrane and volume dynamics during red blood cell development and aging.
  • To elucidate the roles of cytoskeletal structures in red cell genesis and maturation.
  • To identify factors contributing to red cell aging and removal from circulation.

Main Methods:

  • Review of existing literature on red blood cell development and aging.
  • Analysis of the role of cytoskeletal components (microtubules, microfilaments) in cell morphology.

Related Experiment Videos

  • Examination of membrane skeleton remodeling during reticulocyte maturation.
  • Investigation of changes in cell volume, density, and surface properties during the RBC lifespan.

    • Main Results:

    • Cytoskeletal elements are vital for the transition from nucleated precursors to anucleate reticulocytes and their early development.
    • Reticulocyte maturation involves significant cell shape changes and membrane skeleton remodeling, yielding a stable, deformable mature red cell membrane.
    • Volume and density variations in circulating RBCs stem from membrane alterations during reticulocyte maturation.
    • Red cell aging is characterized by surface area reduction, decreased volume, and surface modifications facilitating immunoglobulin binding.

    Conclusions:

    • The development and maturation of red blood cells are intrinsically linked to dynamic changes in cell membrane and volume, orchestrated by the cytoskeleton.
    • While several changes accompany red cell aging, the precise cellular mechanism triggering the removal of senescent red blood cells from circulation requires further definition.
    • Further research is needed to pinpoint the definitive cellular modification responsible for senescent red blood cell clearance.