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Updated: Mar 29, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image
Qiuhong Yang1, Maogang Gong2, Shuang Cai1
1Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.
Background:
A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging.
Methods & Results:
A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3O4) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region.
Conclusion:
This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.
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