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Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser-Based-Techniques
Jean-Luc Cracowski1,2,3, Matthieu Roustit1,2,3
1Université Grenoble Alpes, Grenoble, France.
Microcirculation (New York, N.Y. : 1994)
|November 27, 2015
Summary
Laser-based methods and reactivity tests offer new ways to study skin microcirculation and its functions. These advancements provide reliable tools for assessing endothelial and neurovascular health, aiding in drug evaluation and disease prognosis.
Area of Science:
- Biomedical Engineering
- Dermatology
- Physiology
Background:
- Noninvasive techniques utilizing laser light interaction are crucial for investigating skin microcirculation.
- Understanding skin endothelial and neurovascular function is vital for human health assessment.
Purpose of the Study:
- To explore the advancements in laser-based techniques for studying skin microcirculation.
- To highlight the role of reactivity tests in assessing skin microvascular function.
- To discuss the potential of skin microvascular function as a prognostic biomarker.
Main Methods:
- Utilizing laser Doppler and Laser Speckle Contrast Imaging (LSCI) combined with reactivity tests.
- Employing iontophoresis of vasodilators and topical/intradermal drug delivery to study physiological pathways.
- Leveraging recent technological improvements in microcirculation imaging.
Main Results:
- Reactivity tests (e.g., PORH, LTH, PIV) combined with laser techniques effectively explore skin endothelial and neurovascular function.
- Drug delivery methods have enhanced the understanding of physiological pathways in reactivity tests.
- Improved imaging technologies offer reliable and reproducible tools for microcirculation studies.
Conclusions:
- Advancements in laser-based techniques and reactivity tests provide robust tools for studying skin microcirculation.
- Skin microvascular function assessment holds promise for prognostic applications and drug efficacy evaluation.
- Integrated understanding of physiology and technology enables reliable microcirculation research.
Keywords:
endotheliumiontophoresislaser Dopplerlaser specklelocal thermal hyperemiamicrocirculationmicrodialysispostocclusive hyperemiaskinMore Related Videos
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