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Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity

Xiaoyu Wang1, Caijun Sun2, Pingchao Li2

  • 1Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, Zhejiang, 310027, P. R. China.

Advanced Materials (Deerfield Beach, Fla.)
|November 27, 2015
PubMed

Keywords:
T cellsadenoviruscalcium phosphatepreexisting immunityvaccine engineering

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Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...
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