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Related Experiment Videos

Ketotifen in asthma.

K P Dawson1, D M Fergusson, L J Horwood

  • 1Department of Paediatrics, Christchurch School of Medicine, Christchurch Hospital, New Zealand.

Australian Paediatric Journal
|April 1, 1989
PubMed
Summary
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Ketotifen reduced asthma attacks and school absence in children with moderately severe asthma. However, it did not significantly lower the overall treatment failure rate during withdrawal.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacology
  • Allergy and Immunology

Background:

  • Asthma is a common chronic respiratory disease in children, impacting quality of life and school attendance.
  • Ketotifen, an anti-inflammatory and mast cell stabilizer, is used for asthma management.
  • Evaluating the efficacy of adjunctive ketotifen in pediatric asthma requires rigorous clinical trials.

Purpose of the Study:

  • To assess the efficacy of ketotifen as an add-on therapy for moderately severe pediatric asthma.
  • To evaluate the impact of ketotifen on asthma exacerbations, school absenteeism, and symptom control.
  • To determine the treatment failure rate during a controlled withdrawal phase of regular asthma therapy.

Main Methods:

  • A 22-week, double-blind, placebo-controlled trial involving 60 children aged 5-13 years with moderately severe asthma.

Related Experiment Videos

  • Ketotifen or placebo was added to existing asthma medications.
  • A controlled withdrawal of regular asthma therapy was incorporated into the study design.

    • Main Results:

    • Children receiving ketotifen demonstrated significantly fewer asthma attacks and reduced school absence compared to placebo.
    • Marginally significant improvements were observed in day and night wheezing rates with ketotifen addition.
    • During the withdrawal phase, the failure rate for ketotifen was not significantly lower than for placebo.

    Conclusions:

    • Adjunctive ketotifen therapy shows potential benefits in reducing asthma exacerbations and improving school attendance in children.
    • The observed benefits on wheezing were marginally significant, suggesting a need for further investigation.
    • Ketotifen did not significantly reduce treatment failure rates during the controlled withdrawal of regular asthma therapy.